The U.S. Food and Drug Administration this month approved a new medication that鈥檚 been proven to help people with early symptomatic Alzheimer鈥檚 disease, which includes mild cognitive impairment and the mild dementia stage of Alzheimer鈥檚 disease.
Called Donanemab, this treatment from Eli Lilly will be sold under its brand name, Kisunla, and works as an intravenous infusion injected every four weeks.
Alzheimer鈥檚 has no cure and can鈥檛 be reversed, but the drug can slow cognitive decline. Eli Lilly reported that a year of Kisunla costs $32,000, and the drug does have serious potential side effects, like brain swelling or bleeding.
READ MORE: Report: Alzheimer's and dementia caregivers total 840K in Florida, bear heavy burden
The new drug is bringing hope to hundreds of thousands of Floridians who have the disease or have loved ones who have been diagnosed with it.
Alzheimer鈥檚 is a growing public health crisis in Florida, according to the Alzheimer鈥檚 Association. The non-profit organization estimates that 580,000 people 65 years of age and older live with it in the state, and Miami-Dade County has the highest rate of people in that age group in the country.
What is Alzheimer鈥檚?
A healthy human brain has 100 billion nerve cells or neurons that transmit information to different parts of the brain, muscles, and body organs.
The brain of someone who has Alzheimer鈥檚, however, has an abnormal level of a naturally occurring protein called beta-amyloid. It clumps together to form plaques. Scientists believe these plaques block the cell-to-cell signaling that would otherwise take place. As neurons stop working and die, the brain shrinks over time and it loses most of its functions.
Tau protein buildup is another factor in Alzheimer's disease. This protein helps stabilize the internal skeleton of neurons in the brain through which nutrients and other essential substances travel. With the Alzheimer鈥檚 disease, an abnormal form of tau builds up, leading the internal skeleton to fall apart. That can lead to cell damage and cognitive decline
Should I ask my doctor about it?
Neurologists do recommend speaking to a physician if you鈥檙e having memory problems so they can do certain diagnostic testing. Someone who forgets where they last placed their reading glasses isn鈥檛 likely exhibiting signs.
The people who may be forgetting 鈥減hone numbers you use frequently, are getting lost driving to places that you know, and that you've driven to before, if you're forgetting names and not remembering later, these are worrisome signs,鈥� said Dr. Michael Dobbs, chair of the Clinical Neurosciences Department at Florida Atlantic University鈥檚 Schmidt College of Medicine, where he's also a professor and the clinical affairs associate dean.
鈥淲hen it gets to the point that someone is catching their house on fire because they've left the stove on and forgotten to turn it off after having done that multiple times 鈥� that's kind of too late,鈥� he said.
The mini-mental status exam and the Montreal Cognitive Assessment are two common tests that check for memory abnormalities. The testing may lead to further evaluation.
Taking care of brain health
Dobbs has witnessed the devastating effects of the dementia on loved ones. His older brother was in his late 50s when he died from the disease in 2022.
鈥淚t was really devastating," he told WLRN. "In my family, several people had dementia ... my own brother having it at a younger age, it does worry me personally.鈥�
Added Dobbs: 鈥淭he anxiety of it can really disrupt your mental health if you worry about it too much. Even though several people in my family had Alzheimer's disease or similar diseases, that doesn't mean I'm going to have it. And even if I do someday, I want to live the best life and do everything that I can for other people and my family in the meantime.鈥�
Dobbs urges people to take care of what's in a person's control when it comes to brain health 鈥� exercise, staying active mentally and learning new things.
鈥淭ry art, try a new language. Don't just look at screens and be fed things. Be active," he said. "Try to be social. Get out and meet new people. Try new experiences, and don't put too many things in your body that are harmful."
He advised having a healthy diet and having regular checkups with your doctor are important.
Don鈥檛 鈥榯urn a blind eye'
Joe Baldelomar, of Broward County is a Care and Support Program Director and Research Champion for the Alzheimer鈥檚 Association, who recommends calling the Association鈥檚 helpline.
Baldelomar's father has Alzheimer鈥檚 disease. His family started noticing unusual behavior when their relative started purchasing items advertised through TV commercials.
鈥淣ot one, but like six, seven, eight of the same thing,鈥� said Baldelomar. "The other that we started noticing was his driving. He would come back with the car all scratched up.鈥�
Then a PET scan demonstrated the beta-amyloid buildup that led to the Alzheimer's diagnosis.
Sury Veliz has experienced all the stages of a loved one's Alzheimer's, and is currently dealing with her own diagnosis. She lives in Key Largo and drives 70 miles each way to participate in a drug trial at Mercy Hospital in Miami. She鈥檚 57 and was diagnosed with Alzheimer鈥檚 about five years ago.
鈥淚鈥檓 intentionally in [the study] for people who have the disease and families as well. I went through it with my father and my grandmother 鈥� his mom. So it runs in the family. I鈥檓 next in line right now but because I鈥檓 in the study, I do feel it鈥檚 helping. I鈥檓 remembering things.鈥�
She was eager to participate even if it's a blind drug study, which means she doesn鈥檛 know what drug it is or even if she鈥檚 receiving a placebo. 鈥淚鈥檓 already five years deep into the diagnosis, but I haven鈥檛 seen a decline. I鈥檓 remembering names, phone numbers, addresses.鈥�
Veliz says news of the FDA approval of Donanemab also gives her hope.
鈥淭here鈥檚 something going on in the background,鈥� she said. 鈥淧eople are actually battling this disease.鈥�
Her advice is not to tell someone suffering from Alzheimer鈥檚 that they already said something, or that you just said it to them. 鈥淭hat 鈥榖ut I said, but I already told you, but you already know this鈥� 鈥� that just makes it worse. You have to sit back and re-say the story, or go with the flow.鈥�
鈥淚f you get it, or you know someone that has it or you suspect somebody has it, get checked out,鈥� she said. 鈥淒on鈥檛 be afraid. Don鈥檛 turn a blind eye because it鈥檚 not gonna go away.鈥�
The helpline is available 24/7 at 1-800-272-3900.
